The effects werent subtle
Neither outcome is acceptable during a carefully planned escalation protocol
Obesity is a multi-systemic disease state with several associated complications such as musculoskeletal issues, obstructive sleep apnoea, cardiovascular disease, infertility, and cancer (endometrial, breast, ovarian, prostate, liver, gallbladder, kidney, and colon) as well as significant metabolic sequelae, the most important being type 2 diabetes due to its high morbidity and mortality through micro- and macro-vascular complications such as ischaemic heart disease, stroke, and peripheral vascular disease [3, 4]
Ultimately, patients may be looking for a softer landing than stopping altogether
As observed previously 13 , the putative flavan-3,3,4-triol ( 4 ) was not stable during purification, and confirmatory time-course experiments showed almost complete degradation of the intermediate ( 4 ) within 24 h (Extended Data Fig